The C max was found to be 0.33 ± 0.04 µg/mL and 27.27 ± 9.9 µg/mL for indomethacin and acetaminophen, respectively, at the maximum time ( T max) (h) of 0.5–1 h. Furthermore, a bioanalytical method was successfully implemented after oral administration to determine the pharmacokinetic profiles of indomethacin and acetaminophen in rat plasma. The optimized extraction procedure and parameters influencing the sorbent extraction were systematically investigated by the validated LC-MS/MS method. The filament was prototyped as a 3D-printed sorbent for extracting small molecules using Affinisol TM, polyvinyl alcohol, and triethyl citrate. We fabricated customized filaments using hot-melt extrusion techniques followed by fused filament fabrication-mediated 3D printing technology to rapidly prototype sorbents that extract non-steroidal anti-inflammatory drugs from rat plasma for determining pharmacokinetic profiles. The development of extraction techniques is a modern trend in the bioanalytical sciences. Analytical sample preparation techniques are essential for assessing chemicals in various biological matrices.
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